Medical Information

What's New with BOT+BAL

Botensilimab + balstilimab. The latest marketing authorization, data, and company news, all in one place.

• World first
  Press releaseOct 8, 2026

  Armenia Says Yes to BOT+BAL

  The first conditional marketing authorizations anywhere for Botvymo® (botensilimab) and Evamplix® (balstilimab), in MSS metastatic colorectal cancer after available standard therapies.

• Key publications2024 to 2026

  1,500+ Patients. 9+ Tumor Types. All the Evidence.

  Every key manuscript and congress presentation, sorted by tumor type, with links to the full papers and posters.

• Press releaseJul 13, 2026

  Up to $340M to Power the ROBBIN Phase 3

  A private placement led by Commodore Capital funds the registrational trial of BOT+BAL before surgery in MSS colon cancer.

• Press releaseJan 15, 2026

  Zydus Deal Done: $141M and U.S. Supply Secured

  Agenus's California biologics plants move to Zydus, with committed manufacturing capacity for BOT+BAL.

• Press releaseJan 12, 2026

  France Expands AAC Access

  ANSM approved an updated national protocol under the Autorisation d’Accès Compassionnel (AAC) framework, covering MSS mCRC without active liver metastases, ovarian cancer, and soft-tissue sarcoma.

Botvymo® (botensilimab) and Evamplix® (balstilimab), each received conditional approval for use in combination with the other for the treatment of adult patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC) without active liver metastases who have previously received available standard therapies. Their use in other indications and in other countries remains investigational.