About Agenus

Agenus is a clinical-stage biotechnology company pioneering immunotherapies designed to activate the body’s immune system to fight cancer.

For more than three decades, Agenus has pushed the frontiers of immuno-oncology (IO). Agenus is advancing a comprehensive portfolio of checkpoint inhibitors and immune modulators, combined with cell therapies, designed to expand the reach of immunotherapy—bringing its promise to more patients, more tumor types, and more parts of the world.

At the core of our mission is a belief that immunotherapy should work for everyone. By integrating artificial intelligence, advanced biomarker analytics, and world-class translational science, we’re developing next-generation treatments that harness immune precision to deliver lasting outcomes.

30+
30+ Years of Pioneering Cancer Innovation

"30 years ago, we envisioned a future where the immune system could be harnessed to cure cancer. That vision remains our driving force today: science-led, patient-focused, and unwavering in our mission to transform outcomes."

Garo H. Armen, PhD
Chairman and Chief Executive Officer

Our vision is to broaden the number of patients who benefit from immunotherapy by advancing combination approaches that draw on our diverse portfolio of antibody therapeutics, adoptive cell therapies, and adjuvant and vaccine platforms.

clinical-stage antibody programs
12
US peak revenue potential and lead indication
$1B+
partnership transactions
$1B
2023
2023 Agenus completes enrollment in randomized Phase 2 clinical trial of botensilimab/balstilimab in advanced MSS colorectal cancer.
Agenus presents survival data for botensilimab/balstilimab in advanced MSS colorectal cancer during late-breaking oral presentation at ESMO-GI.
Agenus receives Fast Track Designation for botensilimab and balstilimab in MSS colorectal cancer.
MiNK Therapeutics presents clinical activity and long-term persistence of allogeneic iNKT cells in solid tumors at SITC 2023.
SaponiQx advances vaccine development with the availability of cGMP QS-21 from its proprietary cultured plant cell source
2022
Agenus presents clinical data on botensilimab (next-gen CTLA-4)/balstilimab (PD-1) combination in heavily pretreated, treatment-resistant solid tumors
AGEN1571 (anti-ILT2) enters clinical development
2021
Agenus and BMS enter licensing agreement for AGEN1777 (TIGIT bispecific)
AGEN1777 enters clinical development
Agenus presents data on botensilimab (next-gen CTLA-4) in solid tumors
Agenus publishes data on balstilimab (PD-1)/zalifrelimab (CTLA-4) combination in 2L cervical cancer
2020
Agenus presents clinical data on botensilimab (next-gen CTLA-4)/balstilimab (PD-1) combination in heavily pretreated, treatment-resistant solid tumors
AGEN1571 (anti-ILT2) enters clinical development
2019
Botensilimab (next-gen CTLA-4), AGEN2373 (CD137), and AGEN1423 (CD73-TGFβ) enter clinical development
Agenus and UroGen enter zalifrelimab collaboration for intravesical treatment of urinary tract cancers
2018
MK-4830 (ILT4), INCAGN2385 (LAG-3) and INCAGN02390 (TIM-3) enter clinical development
Agenus and Gilead enter collaboration to develop next-generation immuno-oncology therapies
2017
Balstilimab (PD-1) enters clinical development
FDA approves GSK’s Shingrix® containing QS-21 Stimulon™
2016
Zalifrelimab (CTLA-4); INCAGN1949 (GITR) and INCAGN2385 (OX40) enterclinical development
2015
Agenus and Incyte enter global I-O discovery alliance
Agenus acquires XOMA manufacturing plant and talent
2014
Agenus acquires 4-AB with multiple checkpoint antibody programs
Agenus and Merck enter antibody discovery collaboration
2006
Prophage evaluated in largest neoantigen vaccine Ph3 trial in adjuvant renal cell carcinoma
2000
Agenus completes IPO and becomes publicly traded on Nasdaq under the symbol AGEN
Agenus acquires Aquila Biopharmaceuticals and QS-21 Stimulon™
1999+
Prophage reveals robust clinical responses in melanoma, renal cell carcinoma, colorectal cancer, and other indications
1994
Agenus (previously Antigenics) founded to develop first individualized neoantigen vaccine, Prophage
Agenus Inc.
3 Forbes Road
Lexington, MA 02421-7305
T: +1 (781) 674 4400 | F: +1 (781) 674 4200