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Zalifrelimab (CTLA-4 Antagonist)
Phase 1/2 Study of CTLA-4 Inhibitor AGEN1884 + PD-1 Inhibitor AGEN2034 in Patients With Advanced/Refractory Solid Tumors, With Expansion Into Second-Line Cervical Cancer and Solid Tumors.
ESMO
European Society for Medical Oncology (ESMO)
June 2, 2022
,
Coward, et al.
Cervical
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Zalifrelimab (CTLA-4 Antagonist)
Balstilimab (anti-PD-1) Alone and in Combination with Zalifrelimab (anti-CTLA-4)for Recurrent/Metastatic (R/M) Cervical Cancer (CC) Preliminary Results of Two Independent Ph2 Trials.
ESMO
European Society for Medical Oncology (ESMO) Virtual
June 2, 2022
,
O'Malley, et al.
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Zalifrelimab (CTLA-4 Antagonist)
AGEN1884, an IgG1 anti-CTLA-4 Antibody, Combines Effectively with PD-1 Blockade in Primary Human T Cell Assays and in a Non-human Primate Pharmacodynamic (PD) Model.
AACR
American Association for Cancer Research (AACR)
June 2, 2022
,
Drouin, et al.
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AGEN2373 (CD137 Agonist)
AGEN2373 is a Conditionally-Active Agonist Antibody Targeting the Co-Stimulatory Receptor CD137 for the Treatment of Human Malignancies.