For many patients, there is no greater sense of promise than cancer immunotherapy and it is often the first inquiry we receive. Of course, the concept of cancer immunotherapy is not new, dating back 150 years when William B.

Results from the phase 1/2 study were presented by Bockorny, the principal investigator, during The Society of Gynecologic Oncology (SGO) 2023 Annual Meeting on Women’s Cancer. Results suggested that the clinical benefit of botensilimab plus bastiliimab was superior to that of standard-of-care therapy.

Botensilimab (AGEN1181) in combination with balstilimab (AGEN2034) induced durable responses in patients with resistant/refractory ovarian cancer, according to findings from the phase 1 C-800 study (NCT03860272) presented at the 2023 SGO Annual Meeting on Women’s Cancer.

A year and a half after Agenus withdrew its accelerated approval request for cervical cancer drug balstilimab, the biotech has provided new combo data in ovarian cancer.

In heavily pretreated patients with metastatic colorectal cancer who have microsatellite-stable tumors, the novel combination of the monoclonal antibodies botensilimab and balstilimab showed clinical activity, producing durable responses and an estimated 63% overall survival rate at 12 months, according to a phase Ia/IIb study reported at the 2023 ASCO GI Cancers Symposium.