Careers

We are dedicated scientists, researchers, biotechnologists, physicians, and businesspeople working together toward one goal: minimize the burden of cancers and infections by helping the body heal itself through the power of science.

The work we do at Agenus is cutting edge and deeply motivating. We believe passionately in our technology, in our pipeline, and in our responsibility to deliver on the promise of immunology to treat cancer and infectious disease. If you’re looking for an inspired environment, passionate colleagues, and a culture that nurtures learning, innovation and team success, we invite you to join us.

To learn more about current openings, please contact our Human Resources department.

Current Openings

Jena, Germany

Lexington, MA

Research Associate

Description:

This position will participate in the development of analytical methods to support the CMC characterization and comparability studies of preclinical to clinical monoclonal antibody drug substance and drug product. Responsibilities include characterization of molecular identity, purity, aggregation status, charge isoforms, potency, and stability of monoclonal antibody-based product using HPLC (including SEC, RP-HPLC, IEX, HIC, affinity etc), electrophoresis (including SDS-PAGE, Western blotting, IEF, and capillary electrophoresis C-SDS and C-IEF), ELISA, FRET, qPCR and other microtiter plate-based methods, and non-labeling binding assays (Octet, Biacore, etc); participation in purification of monoclonal antibodies from cell culture harvest or other protein purification process for product characterization; participation in characterization of monoclonal antibody and other protein-based product by peptide mapping and LC-MS; interaction with R&D, QC and Manufacturing groups and presentation of data in group settings.

Education: A BS/MS degree in a scientific discipline plus minimum 4/2 years of relevant experience (preferably in monoclonal antibody analytical development).

Experience: HPLC, Antibody, Protein

Sr. Research Associate

Description:

This position will participate in the development of analytical methods to support the CMC characterization and comparability studies of preclinical to clinical monoclonal antibody drug substance and drug product. Responsibilities include analytical development of MS- and LC-MS based methods for characterization of novel monoclonal antibodies and other protein based product at preclinical and clinical studies; performing MS analysis of intact molecule, isoforms, and fragments generated by various enzyme digestion; peptide mapping analysis for monoclonal antibody sequence and subunit analysis, glycosylation analysis and isoform quantitation by LC-MS; participating in method development for identity, purity, aggregation status, charge isoforms, potency, and stability of monoclonal antibody-based product using HPLC (including SEC, RP-HPLC, IEX, HIC, affinity etc), electrophoresis (including SDS-PAGE, Western blotting, IEF, and capillary electrophoresis C-SDS and C-IEF), and other protein chemistry tools; interaction with R&D, QC and Manufacturing groups and presentation of data in group settings.

Education: A BS/MS degree in a scientific discipline plus minimum 5/3 years of relevant experience in monoclonal antibody or protein-based product characterization by LC-MS, enzymatic digestion, and sample preparation.

Experience: Mass spectrometry

Sr. Scientist, Cell Culture & Process Development

Description:

This position will be responsible for cell culture and upstream process development for multiple monoclonal antibody products intended for preclinical and Phase I clinical studies. Responsibilities will include development of high performance cell culture process from stable pool or selected research cell bank (RCB) of engineered CHO cells in shake flasks and bench-top bioreactors; generation of high titer monoclonal antibodies secreted culture media harvest; purification of multi-gram quantity of mAb for preclinical studies and reference materials; participation in preclinical to Phase I process and product comparability studies; support of CMC process control with project teams and CMO’s.

Requirements:

  • PhD with a minimum of 5 years of experience developing mammalian cell culture process development for protein preferably monoclonal antibody expression;
  • Experiences in cell culture process scale up, scale down, characterization and transfer are required;
  • Demonstrated success in technical proficiency, bioreactor operation, timely delivery of multi-gram quantity of mAb for preclinical studies and reference material use;
  • Understanding data acquisition and process control, and data management is also required, experience in a cGMP production environment is a plus;
  • Other requirements include knowledge and experience in statistics and DOE, interpersonal and organizational skills, oral and written communication skills, ability of multi-tasking effectively and operate both independently and in team settings

Sr. Scientist, Assay Development

Description:

This position will be responsible for assay development in support of CMC/ IND submission of multiple monoclonal antibody-based products. Responsibilities will include development, qualification and transfer of potency assays for characterization, QC release and stability testing of monoclonal antibody drug substance and drug product; non-cell based assay development and implementation to assess antibody-antigen or target binding and ligand blocking activities; cell-based assay development to evaluate Fc effector function activities of mAb including ADCC, CDC and ADP; Support drug substance and drug product formulation development and batch comparison studies with potency assays; Interpret, present and deliver data to appropriate stakeholders; author and review technical reports and sections of regulatory filing; interact with discovery and other development groups on a scientific and strategic level. Assay format should include but not limit to antigen/ cell receptor binding assay by non-labeling BLI (Octet) or SPR (Biacore), labeling ELISA or Luminex assays, FRET, and other plate-, colorimetric- or fluorescence-based assays, cell-based assays, FACS, SDS-PAGE, Western blotting , etc.

Requirements:

  • PhD plus Minimum 5 years of experience developing potency assays used for CMC support in the biotechnology or pharmaceutical industry;
  • Background in immunology, cell biology, protein chemistry or cancer drug development;
  • Experience working in a GMP regulatory environment desirable;
  • Other requirements include knowledge and experience in statistics and DOE, interpersonal and organizational skills, oral and written communication skills, ability of multi-tasking effectively and operate both independently and in team settings

Patent Agent/Technology Specialist

Description:

Agenus is seeking a highly qualified Patent Agent or Technology Specialist with a technical background and Ph.D. in the biological sciences, ideally with an immuno-oncology focus. 4+ years of experience in biotech patent prosecution, FTO analysis and due diligence is preferred. Antibody-related experience is preferred.

Responsibilities include:

  • Contribution to preparation and prosecution of patent applications
  • Assistance in cross-departmental diligence review of acquisition and in-licensing opportunities, including working with business development colleagues to develop and maintain relationships with third parties
  • Assistance with freedom-to-operate, invalidity, and non-infringement analyses of third party patents and applications and other competitive intelligence activities
  • Database searches and review and analysis of patent and technical literature
  • Clear and effective communication with internal and external stakeholders
  • Other administrative, legal, and corporate duties as required

Key qualifications:

  • Ph.D. in the biological sciences, ideally with an immuno-oncology focus, with 4+ years of experience in biotech patent prosecution, FTO analysis, and due diligence preferred
  • Registration to practice before the U.S. Patent and Trademark Office preferred
  • Proven ability to analyze and evaluate technical documents and inventions and to conduct database searches
  • Excellent academics
  • Effective time management skills
  • Team-oriented approach
  • Curious, smart, and hard-working
  • Good judgment, high integrity, and superior writing and communication skills

Sr Research Associate

Description:

Seeking a highly motivated Senior Research Associate to join a group of researchers evaluating novel therapies in the field of cancer immunotherapy. The candidate will explore mechanism of action, combinatorial therapeutic strategies, and elucidate biomarkers to support the identification of companion diagnostics that are predictive of therapeutic response. The successful candidate will work closely with discovery scientists to advance research stage programs into early clinical development, providing both scientific and technical expertise.

Key qualifications:

The position requires a minimum of 8 years of hands-on relevant experience with a track record of success as evidenced by a strong publication record and/or sustained contributions in the biopharmaceutical industry. The candidate should have expertise on a wide range of cellular and biochemical assays, including cell isolation and culture, molecular biology, flow cytometry, cellular immunology assays and some familiarity with in vivo models of immune disease or oncology. Excellent communication skills to present results at intra- and inter-departmental meetings are expected. Experience in multi-dimensional flow cyotmetric analysis is desirable. Qualified candidates should be adept at independently designing, executing and interpreting experiments.

Minimum MS degree in immunology, oncology, biology or related field and a PhD is strongly preferred.

Research Associate

Description:

We are seeking a highly motivated Research Associate to join the Cancer Immunology (T cell Biology) group at Agenus, Lexington, MA. The successful candidate will have a strong background in immunology, molecular immunology and/or oncology research, as evidenced by previous graduate work and co-authorship on peer reviewed publications. He/She will work as part of a dynamic and collaborative global research team to identify and develop novel antibody-based cancer immunotherapies. The successful candidate is expected to have proficiency in a range of immunological techniques including; multi-parameter flow cytometry, primary immune cell cultures and functional assay development; which is complemented by their experience in general molecular/biochemical methodologies. He/she is expected to design, plan and execute experiments both independently and as part of multidisciplinary team of researchers. The successful candidate will have the ability to interpret results, troubleshoot technical hurdles and propose solutions to the team. Excellent written and oral communication skills are required for this position, and he/she is expected to provide clear/concise data summaries in a variety of project team forums. He/she will be also expected to contribute to the preparation of technical documents (example: SOP/ROP), project report summaries, laboratory protocols and other compliance documents.

Responsibilities include:

Key qualifications:

We are seeking an individual who is enthusiastic, self-motivated and has exceptional problem solving and communication skills. A BS/MS degree in biochemistry, molecular biology or related cancer immunology field is required; a MS degree is highly preferred. A minimum of 2-3 yrs experience with primary immune cell assays, general molecular/biochemical techniques and flow cytometry is required for this position. Evidence of an understanding in the principles and techniques employed to characterize antibody-based cancer therapies is highly preferred. He/She should enjoy working independently on project tasks, as well as on more collaborative experiments. Attention to detail, and the ability to maintain clear and accurate research documentation are required, as well as experience with Microsoft Office (and/or other analysis software packages)

A BS/MS degree in biochemistry, molecular biology or related cancer immunology field is required; a MS degree is highly preferred.

Scientist/Sr Scientist

Description:

We are seeking a highly motivated Scientist/Senior Scientist to join the T cell Biology group (Cancer Immunology) at Agenus. A strong background in molecular immunology and/or cancer immunology, as evidenced by peer reviewed publications is required for this position. The successful candidate will work as part of an integrated research team to identify and characterize novel therapeutic targets for cancer immunotherapy. He/she will be expected to work independently, and to design, execute and interpret experiments in the collaborative global research environment at Agenus. In addition, the candidate will lead research initiatives to evaluate cross-talk between signaling networks that contribute to immune suppression and facilitate neoplastic growth. He/she would be tasked with developing this research into novel therapeutic hypotheses, with an expectation that novel findings will be published in impactful journals.

Responsibilities include:

  • Design and execute research plans to discover and validate novel therapeutic concepts in the areas of cancer immunotherapy
  • Contribute in the development and implementation of the cancer immunology research strategy at Agenus
  • Lead the development of novel immune assays to validate the effect of drug candidates on immune activation
  • Evaluate immune readouts (PD endpoints) that can be incorporated in an early clinical development setting
  • Evaluate external cutting-edge technologies for early-stage discovery and clinical biomarker initiatives
  • Represent Agenus as the scientific lead for research projects internally, and with external partners
  • Collaborate with internal teams on the implementation of biomarker assays for early clinical trials
  • Provide input on IND/NDA/BLA preparation activities.
  • Set up collaborations with academic partners and interface with study investigators, scientific and corporate partners
  • Facilitate productive research interactions across groups at Agenus
  • Demonstrate excellent communication skills (interpersonal and in group forums)
  • Mentor and lead research associates, scientists and postdoctoral fellows, as required

Key qualifications:

A PhD or PhD/MD and post-doctoral training in molecular immunology, molecular oncology or cancer immunology is required. A minimum of 3-5 years of research experience with demonstrated academic/industry achievement, as evidenced by publications in high impact journals, is required. Additional experience in antibody-based immunotherapies, molecular biology, in vitro study of human/primate immune cell assays and signal transduction pathways are encouraged. Candidates should have excellent communication skills, be able to distill complex ideas and articulate innovative solutions, and be dedicated to translating basic translational research insights into impactful human therapies.

A PhD or PhD/MD and post-doctoral training in molecular immunology, molecular oncology or cancer immunology is required.