We are dedicated scientists, researchers, biotechnologists, physicians, and businesspeople working together toward one goal: to discover and develop therapies that can unleash the innate power of the body’s immune system to cure hard-to-treat cancers.

We are passionate about the work we do every day at Agenus to deliver on the promise of immuno-oncology. If you’re looking for an inspired environment, passionate colleagues, and a culture that nurtures learning, innovation and team success, we invite you to join us.

To learn more about current openings, please contact our Human Resources department.

Current Openings

Lexington, MA

Development Team Leader, Clinical Affairs (864)


  • Creating and executing a clear, integrated clinical development strategy for immunotherapy that will ultimately lead to regulatory approvals
  • Identifying, developing and implementing immuno-oncology asset and immuno-oncology combination regimens that have a strong mechanistic rationale, the potential to substantially improve upon the current standard of care, and support an aggressive clinical development plan
  • Leading collaborations with world experts (including other companies where appropriate) in the field of immuno-oncology to ensure optimization of the immunotherapy strategy and pipeline
  • Responsible for coordinating a cross functional Team(s) comprised of colleagues from Clinical Development, Medical Affairs, Translational Oncology, Statistics, Clinical Pharmacology, Regulatory, Safety, Project Management, Operations, Commercial Development, and Finance and other functions as determined by the needs of the team
  • Coordinate with the Translational Oncology Lead on the Asset Team in the thoughtful integration of biomarker and companion diagnostic studies into the clinical development strategy for each asset
  • Ensures that the project is managed appropriately per budget
  • Accountable for ensuring that the necessary resources are applied to the project team to support its success
  • Promotes a culture of innovation within the cross-functional team(s) in order to bring forward creative development plans that maximize the potential of each asset
  • May act as point of contact and project representative to governance and other decision-making bodies, including information dissemination and the resolution of critical project issues
  • Leverages line expertise to achieve the team goals
  • Able to engage with Business Development and contribute to efforts to optimize pre and post-PoC immuno oncology portfolio though in-licensing, out-licensing, co-sponsorship, and other collaborative efforts
  • Creates a motivated, committed and engaged project team
  • Models and expects effective team behavior to achieve the project goals
  • Manages key interdivisional interfaces on project issues including but not limited to research, regulatory affairs, development, commercial, medical affairs, manufacturing and operations.

Education and Experience:

  • MD Training Preferred: Proven ability to function effectively across a complex matrix organization with multiple stakeholders and constituents Minimum of 5 years of relevant experience in the pharmaceutical, academic and/or medical research environments having successfully executed a major component of a development program.
  • Significant Phase 1-3 clinical research experience with strong understanding of the elements of drug development programs and experience in their design and execution
  • An organized, independent, self-motivated individual with exceptional presentation, written, and oral communication skills Able to tailor presentations to the knowledge level of the audience to suit their needs and maximize understanding of the topic

Scientist, BioAnalytical Protein Chemist (856)


The company is seeking a PhD-level bioanalytical protein scientist with two to ten years of post-doctoral experience to join our research biochemistry group in Lexington, MA. This is a hands-on laboratory leadership position. Preferred candidates will have extensive experience in the characterization of proteins and the development of assays for the interactions of proteins with their binding partners, and will be broadly knowledgeable and experienced in the use of biophysical and chemical methods for protein analysis including core skills in the use of analytical separation methods, mass spectrometry and/or NMR, and/or protein crystallography. Experience in drug screening, characterization and/or pharmacology is desirable. Candidates should be broadly knowledgeable in the use of various kinds of laboratory instrumentation and automation as well in the use of computers and software as they apply to drug discovery and development. They should also be conversant in peptide chemistry, immunology, pharmacology, and molecular biology. Excellent interpersonal and communication skills are essential.

Education and Experience:

2-10 years post PhD experience, preferably including academic postdoctoral experience or broad industrial experience. See also above Job Duties section for additional details on specific skill and experience requirements. PhD in Biochemistry, Structural Biology, Biophysics or Chemistry. Undergraduate degree in chemistry or biology, or related field. Post-doc experience can be in a different field if relevant to overall capabilities.

Scientist (870)


The incumbent will serve to bridge the Vaccine Biology group and TcR Biology group. Responsibilities will include supervision and execution of studies related to combinatorial immunotherapy (CP blockade with prophage) as well as support of TcR display studies.

Education and Experience:

PhD and/or MD in biomedical sciences with expertise in animal models, tumor immunology, autoimmunity, design, execution, and analyses of complex in vitro and in vivo studies, and a strong ability to present scientific findings to diverse audiences. Candidates should have some supervisory experience tist

Senior Director Molecular Biology, Molecular Biology & Gene Expression (890)


The candidate will effectively build and lead a team of research and translational scientists to create an innovative center of excellence in molecular biology. Identify, develop and implement reporter-based immuno-oncology assays to assess antibody therapeutic potential, using mouse and human cellular systems. Supervise creation of stable engineered cell lines for drug Mechanism of Action (MoA) assessment and product development. Propose and implement novel, innovative, cutting-edge molecular technologies to advance collaborative efforts within R&D platform. Design and coordinate construction of molecular tools for gene delivery and genome engineering, including lentivirus production. Coordinate research activities in functional genomic screens (RNAi, CRISPR). Coordinate research activities in the engineering and development of transgenic mouse strains. Coordinate with biochemistry and structural biology groups in the development of specific reagents that address MoA and biophysical evaluation of potential drug products. Lead collaborations and partnerships in the field of immuno-oncology to ensure optimization of implemented assays. Represent the Molecular Biology platform at scientific and business meetings. Publish novel research findings in high-impact scientific, technical or medical journals. Promote a culture of innovation within the cross-functional teams to enable the translation of novel human therapies. Monitor and evaluate completion of tasks and projects and prepare reports.

Education and Experience:

Candidates with a background in molecular immunology will be preferred for this position. Prior experience in managing scientists and research associates in an industrial setting is necessary. Consistent record of cutting edge research, as evidenced by first- or senior-authored publications. Outstanding presentation and communication skills. Ability to lead, influence and motivate others. Able to distill complex issues and clearly articulate innovative solutions. PhD degree in a relevant scientific field (e.g. molecular biology, cancer genetics, cancer biology, cancer immunology) with minimum of 5-8 years post-doctoral experience in basic or translational research and/or industry setting experience.

Scientist (896)


Agenus is seeking a highly talented and motivated Scientist to join our Immune Education, Cellular Immunology function. In this position you will work as part of an integrated research team focused on identifying novel therapeutic targets, and in the development and characterization of cancer immunotherapeutic agents directed at these targets. Additionally, you will participate in studies focused on our cancer vaccine program. As a member of our Immune Education Group, you will be expected to facilitate, both directly and as part of the group, experiments contributing to the larger team's effort evaluating how our immunotherapeutic drug candidates affect the cross-talk between signaling networks that contribute to immune suppression and neoplastic growth. Specifically, you will be central to identifying novel therapeutic targets and immune-monitoring candidates within the Innate : Adaptive Immune Interface. In this highly collaborative research environment, you will be expected to develop therapeutic hypotheses with the goal of publishing novel findings in high impact journals. This role would involve experimental design and execution (some direct lab work) and recruitment, training (where needed) and supervision of technical staff as well as interpretation and presentation of results.

Education and Experience:

PhD. Work with an interdisciplinary team of scientists and contribute in the development and implementation of the overall Agenus cancer immunology research strategies. Evaluate immune readouts that can be incorporated in early clinical development. Evaluate external cutting-edge technologies for early-stage discovery and clinical biomarker initiatives as well as competitive evaluation. Represent Agenus as the scientific lead for research projects internally, and with external partners. Provide scientific input on IND/NDA/BLA preparation activities. Interface with study investigators, scientific and corporate collaborators and contribute generously to the overall science base at Agenus.

Research Associate/Sr. Research Associate (898)


Seeking a highly motivated Research Associate/Senior Research Associate to join a group of researchers evaluating novel personalized vaccines in the field of cancer immunotherapy. The candidate will explore vaccine design parameters, mechanism of action and potential for synergy with other therapeutic immune modulating strategies. The successful candidate will work closely with discovery scientists to advance research stage programs into early clinical development, providing both scientific and technical expertise.

Education and Experience:

Minimum MS degree in immunology, oncology, biology or related field and a PhD is strongly preferred. The position requires a minimum of 5 - 8 years of hands-on relevant experience with a track record of success as evidenced by a strong publication record and/or sustained contributions in the biopharmaceutical industry. The candidate should have expertise on a wide range of cellular assays including cell isolation and culture, flow cytometry, cellular immunology assays and some familiarity with in vivo models of immune disease or oncology. Excellent communication skills to present results at intra- and inter-departmental meetings are expected. Experience in multi-dimensional flow cyotmetric analysis is desirable. Qualified candidates should be adept at independently designing, executing and interpreting experiments.

Scientist, Vaccine Research (897)


We are seeking a highly motivated Scientist/Senior Scientist to join the Vaccine Research group (Cancer Immunology) at Agenus, Lexington, MA. A strong background in molecular immunology, T cell signaling and/or cancer immunology, as evidenced by peer reviewed publications is required for this position. The successful candidate will be responsible for evaluation of autologous tumor derived and other personalized, yet synthetic/recombinant, cancer vaccine candidates in animal models as stand-alone therapeutics and in combination with other immune modulating agents. Successful interaction with Agenus’ bioinformatics team to leverage next generation sequencing information for cancer vaccine design will be critical. Evaluation of the company’s existing adjuvants and exploration of other novel adjuvants will be an important component of this research. He/she will be expected to work independently, and to design, execute and interpret experiments in the collaborative global research environment at Agenus. He/she would be tasked with developing this research into novel therapeutic hypotheses, with an expectation that novel findings will be published in impactful journals.


  • Design and execute research plans to discover and validate novel therapeutic concepts in the areas of cancer immunotherapy
  • Contribute in the development and implementation of the cancer immunology research strategy at Agenus
  • Evaluate immune readouts (PD endpoints) that can be incorporated in an early clinical development setting
  • Represent Agenus as the scientific lead for research projects internally, and with external partners
  • Provide input on IND/NDA/BLA preparation activities.
  • Set up collaborations with academic partners and interface with study investigators, scientific and corporate partners
  • Facilitate productive research interactions across groups at Agenus
  • Demonstrate excellent communication skills (interpersonal and in group forums)
  • Mentor and lead research associates, scientists and postdoctoral fellows, as required


A PhD or PhD/MD and post-doctoral training in molecular immunology, molecular oncology or cancer immunology is required. A minimum of 3-5 years of research experience with demonstrated academic/industry achievement, as evidenced by publications in high impact journals, is required. Experience with murine tumor models including vaccine based prevention and treatment protocols as well as immune monitoring assays are required skills. Candidates should have excellent communication skills, be able to distill complex ideas and articulate innovative solutions, and be dedicated to translating basic translational research insights into impactful human therapies.