Careers

We are dedicated scientists, researchers, biotechnologists, physicians, and businesspeople working together toward one goal: minimize the burden of cancers and infections by helping the body heal itself through the power of science.

The work we do at Agenus is cutting edge and deeply motivating. We believe passionately in our technology, in our pipeline, and in our responsibility to deliver on the promise of immunology to treat cancer and infectious disease. If you’re looking for an inspired environment, passionate colleagues, and a culture that nurtures learning, innovation and team success, we invite you to join us.

To learn more about current openings, please contact our Human Resources department.

Current Openings

Jena, Germany

Lexington, MA

Research Associate

Description:

This position will participate in the development of analytical methods to support the CMC characterization and comparability studies of preclinical to clinical monoclonal antibody drug substance and drug product. Responsibilities include characterization of molecular identity, purity, aggregation status, charge isoforms, potency, and stability of monoclonal antibody-based product using HPLC (including SEC, RP-HPLC, IEX, HIC, affinity etc), electrophoresis (including SDS-PAGE, Western blotting, IEF, and capillary electrophoresis C-SDS and C-IEF), ELISA, FRET, qPCR and other microtiter plate-based methods, and non-labeling binding assays (Octet, Biacore, etc); participation in purification of monoclonal antibodies from cell culture harvest or other protein purification process for product characterization; participation in characterization of monoclonal antibody and other protein-based product by peptide mapping and LC-MS; interaction with R&D, QC and Manufacturing groups and presentation of data in group settings.

Education: A BS/MS degree in a scientific discipline plus minimum 4/2 years of relevant experience (preferably in monoclonal antibody analytical development).

Experience: HPLC, Antibody, Protein

Sr. Research Associate

Description:

This position will participate in the development of analytical methods to support the CMC characterization and comparability studies of preclinical to clinical monoclonal antibody drug substance and drug product. Responsibilities include analytical development of MS- and LC-MS based methods for characterization of novel monoclonal antibodies and other protein based product at preclinical and clinical studies; performing MS analysis of intact molecule, isoforms, and fragments generated by various enzyme digestion; peptide mapping analysis for monoclonal antibody sequence and subunit analysis, glycosylation analysis and isoform quantitation by LC-MS; participating in method development for identity, purity, aggregation status, charge isoforms, potency, and stability of monoclonal antibody-based product using HPLC (including SEC, RP-HPLC, IEX, HIC, affinity etc), electrophoresis (including SDS-PAGE, Western blotting, IEF, and capillary electrophoresis C-SDS and C-IEF), and other protein chemistry tools; interaction with R&D, QC and Manufacturing groups and presentation of data in group settings.

Education: A BS/MS degree in a scientific discipline plus minimum 5/3 years of relevant experience in monoclonal antibody or protein-based product characterization by LC-MS, enzymatic digestion, and sample preparation.

Experience: Mass spectrometry

Sr. Scientist, Cell Culture & Process Development

Description:

This position will be responsible for cell culture and upstream process development for multiple monoclonal antibody products intended for preclinical and Phase I clinical studies. Responsibilities will include development of high performance cell culture process from stable pool or selected research cell bank (RCB) of engineered CHO cells in shake flasks and bench-top bioreactors; generation of high titer monoclonal antibodies secreted culture media harvest; purification of multi-gram quantity of mAb for preclinical studies and reference materials; participation in preclinical to Phase I process and product comparability studies; support of CMC process control with project teams and CMO’s.

Requirements:

  • PhD with a minimum of 5 years of experience developing mammalian cell culture process development for protein preferably monoclonal antibody expression;
  • Experiences in cell culture process scale up, scale down, characterization and transfer are required;
  • Demonstrated success in technical proficiency, bioreactor operation, timely delivery of multi-gram quantity of mAb for preclinical studies and reference material use;
  • Understanding data acquisition and process control, and data management is also required, experience in a cGMP production environment is a plus;
  • Other requirements include knowledge and experience in statistics and DOE, interpersonal and organizational skills, oral and written communication skills, ability of multi-tasking effectively and operate both independently and in team settings

Sr. Scientist, Assay Development

Description:

This position will be responsible for assay development in support of CMC/ IND submission of multiple monoclonal antibody-based products. Responsibilities will include development, qualification and transfer of potency assays for characterization, QC release and stability testing of monoclonal antibody drug substance and drug product; non-cell based assay development and implementation to assess antibody-antigen or target binding and ligand blocking activities; cell-based assay development to evaluate Fc effector function activities of mAb including ADCC, CDC and ADP; Support drug substance and drug product formulation development and batch comparison studies with potency assays; Interpret, present and deliver data to appropriate stakeholders; author and review technical reports and sections of regulatory filing; interact with discovery and other development groups on a scientific and strategic level. Assay format should include but not limit to antigen/ cell receptor binding assay by non-labeling BLI (Octet) or SPR (Biacore), labeling ELISA or Luminex assays, FRET, and other plate-, colorimetric- or fluorescence-based assays, cell-based assays, FACS, SDS-PAGE, Western blotting , etc.

Requirements:

  • PhD plus Minimum 5 years of experience developing potency assays used for CMC support in the biotechnology or pharmaceutical industry;
  • Background in immunology, cell biology, protein chemistry or cancer drug development;
  • Experience working in a GMP regulatory environment desirable;
  • Other requirements include knowledge and experience in statistics and DOE, interpersonal and organizational skills, oral and written communication skills, ability of multi-tasking effectively and operate both independently and in team settings

Patent Agent/Technology Specialist

Description:

Agenus is seeking a highly qualified Patent Agent or Technology Specialist with a technical background and Ph.D. in the biological sciences, ideally with an immuno-oncology focus. 4+ years of experience in biotech patent prosecution, FTO analysis and due diligence is preferred. Antibody-related experience is preferred.

Responsibilities include:

  • Contribution to preparation and prosecution of patent applications
  • Assistance in cross-departmental diligence review of acquisition and in-licensing opportunities, including working with business development colleagues to develop and maintain relationships with third parties
  • Assistance with freedom-to-operate, invalidity, and non-infringement analyses of third party patents and applications and other competitive intelligence activities
  • Database searches and review and analysis of patent and technical literature
  • Clear and effective communication with internal and external stakeholders
  • Other administrative, legal, and corporate duties as required

Key qualifications:

  • Ph.D. in the biological sciences, ideally with an immuno-oncology focus, with 4+ years of experience in biotech patent prosecution, FTO analysis, and due diligence preferred
  • Registration to practice before the U.S. Patent and Trademark Office preferred
  • Proven ability to analyze and evaluate technical documents and inventions and to conduct database searches
  • Excellent academics
  • Effective time management skills
  • Team-oriented approach
  • Curious, smart, and hard-working
  • Good judgment, high integrity, and superior writing and communication skills

Patent Attorney

Description:

Agenus is seeking a highly qualified Patent Attorney with a technical background and Ph.D. in the biological sciences, ideally with an immuno-oncology focus. Significant experience in biotech patent prosecution, FTO analysis and due diligence is required, and significant antibody-related experience is preferred. This position will be a key contributor to assisting the company in developing and moving their IP portfolio forward. Registration to practice before the United States Patent and Trademark Office along with an admission to a state bar is required. Excellent academics and strong written and verbal communication skills are necessary as this position will be interfacing with the scientists and upper management.

Responsibilities include:

  • Contribution to preparation and prosecution of patent applications
  • Assistance in cross-departmental diligence review of acquisition and in-licensing opportunities, including working with business development colleagues to develop and maintain relationships with third parties
  • Assistance with freedom-to-operate, invalidity, and non-infringement analyses of third party patents and applications and other competitive intelligence activities
  • Database searches and review and analysis of patent and technical literature
  • Clear and effective communication with internal and external stakeholders
  • Other administrative, legal, and corporate duties as required

Key qualifications:

  • Ph.D. in the biological sciences, ideally with an immuno-oncology focus, with 4+ years of experience in biotech patent prosecution, FTO analysis, and due diligence preferred
  • Registration to practice before the U.S. Patent and Trademark Office preferred
  • Proven ability to analyze and evaluate technical documents and inventions and to conduct database searches
  • Excellent academics
  • Effective time management skills
  • Team-oriented approach
  • Curious, smart, and hard-working
  • Good judgment, high integrity, and superior writing and communication skills